Down syndrome

noun

variants or Down's syndrome

: a congenital condition characterized especially by developmental delays, usually mild to moderate impairment in cognitive functioning, short stature, upward slanting eyes, a flattened nasal bridge, broad hands with short fingers, decreased muscle tone, and by trisomy of the human chromosome numbered 21

called also trisomy 21

Examples of Down syndrome in a Sentence

Recent Examples on the Web

In its mission to represent, and change society’s perspective, the organization helps create opportunities for individuals with autism, Down syndrome, cerebral palsy, Fragile X Syndrome and intellectual disability. —Christina Mayo, Miami Herald, 9 July 2025

The Barbie Fashionistas line features more than 175 looks across various skin tones, body types and disabilities, including previous additions like a blind Barbie, a Barbie with Down syndrome and a Barbie with hearing aids. —Piper Heath follow, Los Angeles Times, 9 July 2025

Other dolls in the Fashionistas line include a blind Barbie who carries a cane, a Barbie with Down syndrome, and a Barbie who uses a wheelchair. —Cara Lynn Shultz, People.com, 8 July 2025

The company said the blind Barbie and a doll with Down syndrome were among the most popular Fashionista dolls globally in 2024. —Brenda Goodman, CNN Money, 8 July 2025

Word History

Etymology

J. L. H. Down †1896 English physician

First Known Use

1961, in the meaning defined above

Rhymes for Down syndrome

• acrosome
• aerodrome
• catacomb
• centrosome
• chromosome
• cytochrome
• hippodrome
• honeycomb
• liposome
• meerschaum
• metronome
• microtome

Kids Definition

Down syndrome

noun

ˈdau̇n-

variants or Down's syndrome

ˈdau̇n(z)-

: a genetic condition characterized especially by developmental delays, by distinctive physical traits (as short stature and upward slanting eyes), and by the presence of three chromosomes numbered 21 in human beings

Etymology

named for J.L.H. Down, 1828–1896, English doctor

Medical Definition

Down syndrome

noun

variants or Down's syndrome

: a congenital condition characterized especially by developmental delays, usually mild to moderate impairment in cognitive functioning, short stature, relatively small head, upward slanting eyes usually with epicanthal folds, flattened nasal bridge, broad hands with short fingers, decreased muscle tone, and by trisomy of the human chromosome numbered 21

called also Down, Down's, trisomy 21