Down syndrome

noun

variants or Down's syndrome

: a congenital condition characterized especially by developmental delays, usually mild to moderate impairment in cognitive functioning, short stature, upward slanting eyes, a flattened nasal bridge, broad hands with short fingers, decreased muscle tone, and by trisomy of the human chromosome numbered 21

called also trisomy 21

Examples of Down syndrome in a Sentence

Recent Examples on the Web

The new doll is part of Mattel’s Fashionistas collection, which includes dolls with a diverse range of skin tones, hair textures, body types and health conditions, including type 1 diabetes, Down syndrome and blindness. —Jacqueline Howard, CNN Money, 12 Jan. 2026

Since then, the lineup has expanded to include Barbies who are blind, use wheelchairs, have Down syndrome, have prosthetic limbs, have vitiligo, or wear hearing aids. —Sujita Sinha, Interesting Engineering, 12 Jan. 2026

The new Barbie joins the Fashionistas Line, which includes dolls with type 1 diabetes, Down syndrome, and blindness. —Sarah Scott, Parents, 12 Jan. 2026

Previous additions include Barbie dolls with Type 1 diabetes, Down syndrome and blindness. —Cerys Davies, Los Angeles Times, 12 Jan. 2026

Word History

Etymology

J. L. H. Down †1896 English physician

First Known Use

1961, in the meaning defined above

Rhymes for Down syndrome

• acrosome
• aerodrome
• catacomb
• centrosome
• chromosome
• cytochrome
• hippodrome
• honeycomb
• liposome
• meerschaum
• metronome
• microtome

Kids Definition

Down syndrome

noun

ˈdau̇n-

variants or Down's syndrome

ˈdau̇n(z)-

: a genetic condition characterized especially by developmental delays, by distinctive physical traits (as short stature and upward slanting eyes), and by the presence of three chromosomes numbered 21 in human beings

Etymology

named for J.L.H. Down, 1828–1896, English doctor

Medical Definition

Down syndrome

noun

variants or Down's syndrome

: a congenital condition characterized especially by developmental delays, usually mild to moderate impairment in cognitive functioning, short stature, relatively small head, upward slanting eyes usually with epicanthal folds, flattened nasal bridge, broad hands with short fingers, decreased muscle tone, and by trisomy of the human chromosome numbered 21

called also Down, Down's, trisomy 21